General Information

  • ID:  hor003995
  • Uniprot ID:  A0A977SQC6
  • Protein name:  Pyrokinin-1
  • Gene name:  NA
  • Organism:  Tenebrio molitor (Yellow mealworm beetle)
  • Family:  Pyrokinin family
  • Source:  Animal
  • Expression:  NA
  • Disease:  NA
  • Comments:  NA
  • Taxonomy:  Tenebrio (genus), Tenebrioninae (subfamily), Tenebrionidae (family), Tenebrionoidea (superfamily), Cucujiformia (infraorder), Polyphaga (suborder), Coleoptera (order), Endopterygota (cohort), Neoptera (infraclass), Pterygota (subclass), Dicondylia, Insecta (class), Hexapoda (subphylum), Pancrustacea, Mandibulata, Arthropoda (phylum), Panarthropoda, Ecdysozoa, Protostomia, Bilateria, Eumetazoa, Metazoa (kingdom), Opisthokonta, Eukaryota (superkingdom), cellular organisms
  • GO MF:  GO:0005184 neuropeptide hormone activity
  • GO BP:  GO:0007218 neuropeptide signaling pathway; GO:0042811 pheromone biosynthetic process
  • GO CC:  GO:0005576 extracellular region

Sequence Information

  • Sequence:  HVVNFTPRL
  • Length:  9(96-104)
  • Propeptide:  MERIILVNLAVLCVAILLSEVVLSVPHYGSHQVSVRRERNDDKKQSYMWFGPRLGRKKRNSNIDPYRNREREQLATLLDVIQDSPWAIVAVNGKRHVVNFTPRLGRESGEEFVSSAAEDRWLQDPEMSGEMLSQRSPPFAPRLGRHLSPFSPRLGRENDKNLF
  • Signal peptide:  NA
  • Modification:  NA
  • Glycosylation:  NA
  • Mutagenesis:  NA

Activity

  • Function:  NA
  • Mechanism:  NA
  • Cross BBB:  NA
  • Target:  NA
  • Target Unid:  NA
  • IC50: NA
  • EC50: NA
  • ED50: NA
  • kd: NA
  • Half life: NA

Structure

  • Disulfide bond:  NA
  • Structure ID:  NA

  • Structure: (PDB_ID-from https://www.rcsb.org/; AlphaFold_DB_ID-from https://alphafold.ebi.ac.uk/; hordbxxxxxx_AF2.pdb was predicted structure by AlphaFold2; hordbxxxxxx_ESM.pdb was predicted structure by ESMFold)
    •    hor003995_AF2.pdbhor003995_ESM.pdb

Physical Information

Mass: 122514 Formula: C50H79N15O12
Absent amino acids: ACDEGIKMQSWY Common amino acids: V
pI: 10.55 Basic residues: 2
Polar residues: 2 Hydrophobic residues: 4
Hydrophobicity: 16.67 Boman Index: -1281
Half-Life: 3.5 hour Half-Life Yeast: 10 min
Half-Life E.Coli: >10 hour Aliphatic Index 107.78
Instability Index: -1618.89 Extinction Coefficient cystines: 0
Absorbance 280nm: 0

Literature

  • PubMed ID:  18201799
  • Title:  Neuropeptides of the Beetle, Tenebrio Molitor Identified Using MALDI-TOF Mass Spectrometry and Deduced Sequences From the Tribolium Castaneum Genome